Antibiotic use in the ICU

754Improving antibiotic delivery in the ICU

Aerosolized Antibiotic Therapy in the Icu

EVIDENCE DEFINITIONS  Class I: Prospective randomized controlled trial.  Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies.  Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion.  Technology assessment: A technology study which doe...

Towards better ICU antibiotic dosing.

OBJECTIVE To review the recent pharmacokinetic and pharmacodynamic reports of some of the commonly used antibiotics in critically ill patients and recommend alterations in their administration to improve their efficacy. DATA SOURCES Relevant articles and published reviews on aminoglycoside, third and fourth generation cephalosporins, vancomycin and ciprofloxacin dosing in critically ill patie...

The Ecology of Antibiotic Use in the ICU: Homogeneous Prescribing of Cefepime but Not Tazocin Selects for Antibiotic Resistant Infection

BACKGROUND Antibiotic homogeneity is thought to drive resistance but in vivo data are lacking. In this study, we determined the impact of antibiotic homogeneity per se, and of cefepime versus antipseudomonal penicillin/β-lactamase inhibitor combinations (APP-β), on the likelihood of infection or colonisation with antibiotic resistant bacteria and/or two commonly resistant nosocomial pathogens (...

Top ten list in antibiotic policy in the ICU.

Over the last decade, the study of mortality in patients with ventilator-associated pneumonia (VAP) has raised a controversial question: whether the patient died of VAP or merely with VAP. Obviously, complications are a major risk in a patient with an infectious disease who does not receive treatment. Equally, if treatment is administered but the antibiotic choice is unsuitable, no beneficial i...